ea0016p461 | Neuroendocrinology | ECE2008
Arosio Maura
, Filopanti Marcello
, Montefusco Laura
, Olgiati Luca
, Lucia Ronchi Cristina
, Losa Marco
, La Porta Carmen
, Coletti Francesca
, Lania Andrea
, Beck-Peccoz Paolo
, Spada Anna
Background: The d3-growth hormone receptor (GHR) polymorphism is a common variant characterized by genomic deletion of exon 3 (d3) of the GHR gene. It could be linked to a better growth response to GH, but the findings are controversial. Due to the lack of IGF-I feedback on the tumoral GH secretion, acromegaly seems to be a good model to study functional characteristics of this polymorphism. Aim of the study was to investigate possible influences of d3-GHR on GH and IGF-I rela...